New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and <i>in silico</i> studies.

Elkady, Hazem; Elwan, Alaa; El-Mahdy, Hesham A; Doghish, Ahmed S; Ismail, Ahmed; Taghour, Mohammed S; Elkaeed, Eslam B; Eissa, Ibrahim H; Dahab, Mohammed A; Mahdy, Hazem A; Khalifa, Mohamed M

New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies.

Elkady, Hazem; Elwan, Alaa; El-Mahdy, Hesham A; Doghish, Ahmed S; Ismail, Ahmed; Taghour, Mohammed S; Elkaeed, Eslam B; Eissa, Ibrahim H; Dahab, Mohammed A; Mahdy, Hazem A; Khalifa, Mohamed M.

Afiliação

Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Elwan A; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
El-Mahdy HA; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Doghish AS; Biochemistry Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr, Egypt.
Ismail A; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Taghour MS; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Dahab MA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Khalifa MM; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.

J Enzyme Inhib Med Chem ; 37(1): 397-410, 2022 Dec.

Article em En | MEDLINE | ID: mdl-34961427

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Benzoxazóis/farmacologia; Desenho de Fármacos; Inibidores de Proteínas Quinases/farmacologia; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores; Antineoplásicos/síntese química; Antineoplásicos/química; Benzoxazóis/síntese química; Benzoxazóis/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Simulação de Acoplamento Molecular; Estrutura Molecular; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Relação Estrutura-Atividade; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

Anti-proliferative; VEGFR-2 inhibitors; apoptosis; benzoxazole

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzoxazóis / Desenho de Fármacos / Apoptose / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito País de publicação: Reino Unido

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google