Formulation and Evaluation of Dermatological Product Containing Niacinamide.

ABSTRACT

In this study, niacinamide-based skin creams were formulated and evaluated. Niacinamide (also known as nicotinamide, 3-pyridinecarboxamide) is a physiologically active form of niacin or vitamin B3. Niacinamide, a derivative of niacin, has the ability to treat some skin conditions including aging skin. Quality of the product was assessed by using high-performance thin-layer chromatography (HPTLC) method to determine the content of niacinamide. No change in the physical properties was observed; the pH was in a proper range. The formulations showed good spreadability, no evidence of phase separation, and good consistency during this study period. From this study, it can be concluded that it is possible to develop creams that contain niacinamide having antiaging property and used as a barrier to protect skin.