ALT, alanine aminotransferase; AST, aspartate aminotransferase; ApoA1, apolipoprotein A1; BA, bile acid; BSH, bile salt hydrolase; Bile salt hydrolase; Biomarkers; C4; C4, 7α-hydroxy-4-cholesten-3-one; CA, cholic acid; CDCA, chenodeoxycholic acid; CYP7A1, cytochrome P450 7A1; DCA, deoxycholic acid; Deoxycholic acid; FGF21; FGF21, fibroblast growth factor 21; FXR, farnesoid X receptor; GCA, glyco-cholic acid; GCDCA, glyco-chenodeoxycholic acid; GDCA, glyco-deoxycholic acid; GUDCA, glyco-ursodeoxycholic acid; HFF, hepatic fat fraction; HbA1c, glycated haemoglobin; LC, liquid chromatography; LCA, lithocholic acid; MS, mass spectrometry; Microbiome; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; PEGylated, polyethylene glycol-conjugated; PGBF, pegbelfermin; PRO-C3, N-terminal type III collagen propeptide; QD, once daily; QW, once weekly; T2DM, type 2 diabetes mellitus; TCA, tauro-cholic acid; TCDCA, tauro-chenodeoxycholic acid; TDCA, tauro-deoxycholic acid; UDCA, ursodeoxycholic acid; baiCD, 7α-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductase; baiH, 7ß-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductase; hdhA, 7-alpha-hydroxysteroid dehydrogenase