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IgE and IgG Anti-Thyroid Autoantibodies in Chinese Patients With Chronic Spontaneous Urticaria and a Literature Review.
Zhang, Liming; Qiu, Li; Wu, Jian; Qi, Yumeng; Wang, Hexiao; Qi, Ruiqun; Yao, Xu; Zhu, Hong; Li, Yuzhen; Hao, Siyu; Lu, Qianjin; Long, Hai; Lian, Shi; Zhang, Haiping; Zhu, Wei; Lai, Wei; Su, Xiangyang; Lu, Rongbiao; Guo, Zaipei; Li, Jingyi; Li, Mengmeng; Liu, Quanzhong; Wang, Huiping; He, Li; Nong, Xiang; Li, Fuqiu; Li, Yang; Yao, Chunli; Xu, Jinhua; Tang, Hui; Wang, Duoqin; Li, Zhenlu; Yu, Huiqian; Xiao, Shengxiang; An, Jingang; Pu, Xiongming; Yu, Shirong; Zhang, Jianzhong; Chen, Xue; Gao, Xinghua; Chen, Hongduo; Xiao, Ting.
Afiliação
  • Zhang L; Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.
  • Qiu L; Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.
  • Wu J; Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.
  • Qi Y; Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.
  • Wang H; Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.
  • Qi R; Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.
  • Yao X; Department of Allergy and Rheumatology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
  • Zhu H; Department of Allergy and Rheumatology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
  • Li Y; Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Hao S; Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Lu Q; Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Long H; Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Lian S; Department of Dermatology, Xuan Wu Hospital Capital Medical Univerisity, Beijing, China.
  • Zhang H; Department of Dermatology, Xuan Wu Hospital Capital Medical Univerisity, Beijing, China.
  • Zhu W; Department of Dermatology, Xuan Wu Hospital Capital Medical Univerisity, Beijing, China.
  • Lai W; Department of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Su X; Department of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Lu R; Department of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Guo Z; Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
  • Li J; Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
  • Li M; Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
  • Liu Q; Department of Dermatology, Tianjin Medical University General Hospital, Tianjin, China.
  • Wang H; Department of Dermatology, Tianjin Medical University General Hospital, Tianjin, China.
  • He L; Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
  • Nong X; Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
  • Li F; Department of Dermatology, The Second Hospital of Jilin University, Changchun, China.
  • Li Y; Department of Dermatology, The Second Hospital of Jilin University, Changchun, China.
  • Yao C; Department of Dermatology, The Second Hospital of Jilin University, Changchun, China.
  • Xu J; Department of Dermatology, Huashan Hospital, Fudan Univeristy, Shanghai, China.
  • Tang H; Department of Dermatology, Huashan Hospital, Fudan Univeristy, Shanghai, China.
  • Wang D; Department of Dermatology, Huashan Hospital, Fudan Univeristy, Shanghai, China.
  • Li Z; Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou, China.
  • Yu H; Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou, China.
  • Xiao S; Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
  • An J; Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
  • Pu X; Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Key Laboratory of Dermatology Research (XJYS1707), Urumqi, China.
  • Yu S; Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Key Laboratory of Dermatology Research (XJYS1707), Urumqi, China.
  • Zhang J; Department of Dermatology, Peking University People's Hospital, Beijing, China.
  • Chen X; Department of Dermatology, Peking University People's Hospital, Beijing, China.
  • Gao X; Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.
  • Chen H; Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China. hongduochen@hotmail.com.
  • Xiao T; Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China. cmuxt@126.com.
Allergy Asthma Immunol Res ; 14(1): 131-142, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34983113
ABSTRACT
Immunoglobulin (Ig) E and IgG anti-thyroid autoantibodies (AAbs) play important roles in the immunopathogenesis of chronic spontaneous urticaria (CSU). To date, association of IgE and IgG AAbs with Chinese CSU patients has not been fully investigated. We aimed to explore prevalence rates of IgE and IgG AAbs in Chinese CSU patients and their association with clinical and laboratory parameters. Serum IgE and IgG AAbs against thyroid peroxidase (TPO) and thyroglobulin (TG), total IgE (tIgE) and specific IgEs were measured using enzyme-linked immunosorbent assay, chemiluminescence microparticle immunoassay and immunoblotting. Meta-analyses and literature review were conducted. The meta-analyses indicated that CSU cases were 4.98, 6.90 and 6.68 times more likely to have positive anti-TPO IgE, anti-TPO IgG and anti-TG IgG (all P < 0.001) compared with controls, respectively, and revealed a positive correlation between the prevalence rates of anti-TPO IgE and anti-TPO IgG (r = 0.53, P = 0.025). A total of 1,100 Chinese Han adult CSU patients and 1,100 ethnicity-, age- and sex-matched healthy controls were recruited from 15 centers. Prevalence rates of anti-TPO IgE, anti-TPO IgG, anti-TG IgE or anti-TG IgG in the patients were all significantly higher than those in the controls. Significant correlations were observed between prevalence rates of anti-TPO IgE and anti-TPO IgG (r = 0.297, P < 0.001) as well as between those of anti-TG IgE and anti-TG IgG in the patients (r = 0.137, P < 0.001). Patients with anti-TPO IgE or anti-TPO IgG had significantly lower tIgE levels (P < 0.001). Positive anti-TPO IgE, positive anti-TPO IgG and tIgE < 40 IU/mL were independent predictors of antihistamine-refractory cases. In conclusion, the prevalence rates of IgE and IgG AAbs in Chinese CSU patients are significantly elevated and reciprocally correlated. This study verifies the results of previous case-control studies of CSU patients from other populations and ethnicities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Allergy Asthma Immunol Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Allergy Asthma Immunol Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China