Doença de Alzheimer; Disfunção Cognitiva; Microbioma Gastrointestinal; Doença de Alzheimer/tratamento farmacológico; Animais; Compostos de Bifenilo; Cognição; Disfunção Cognitiva/tratamento farmacológico; Glicogênio Sintase Quinase 3 beta; Lignanas; Masculino; Camundongos; Doenças Neuroinflamatórias

AD, Alzheimer's disease; APH-1, anterior pharynx-defective-1; APP, amyloid precursor protein; Aß, ß-amyloid; BACE-1, ß-site APP cleaving enzyme-1; Bcl-2, B cell lymphoma-2; CDK5, cyclin-dependent kinase 5; CMC-Na, sodium carboxymethylcellulose; Cognitive deficits; GSK-3ß, glycogen synthase kinase 3ß; Gut microbiota; HO, Honokiol; HPLC, high performance liquid chromatography; Honokiol nanoscale drug delivery system; IDE, insulin degrading enzyme; IL-1ß, interleukin 1ß; IL-6, interleukin 6; JNK, c-Jun N-terminal kinase; MCT, Medium-chain triglycerides; MWMT, Morris Water Maze test; NEP, neprilysin; NFTs, neurofibrillary tangles; Nano-HO, honokiol nanoscale drug delivery system; Neuroinflammation; PBS, phosphate-buffered saline; PDI, poly-dispersity index; PS-1, presenilin-1; ROS, reactive oxygen species; TEM, transmission electron microscope; TNF-α, tumor necrosis factor; Tau protein hyperphosphorylation; TgCRND8 mice; WT, wild type; ZP, zeta potential