Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression.

Qian, Meijia; Yan, Fangjie; Wang, Weihua; Du, Jiamin; Yuan, Tao; Wu, Ruilin; Zhao, Chenxi; Wang, Jiao; Lu, Jiabin; Zhang, Bo; Lin, Nengming; Dong, Xin; Dai, Xiaoyang; Dong, Xiaowu; Yang, Bo; Zhu, Hong; He, Qiaojun

Qian, Meijia; Yan, Fangjie; Wang, Weihua; Du, Jiamin; Yuan, Tao; Wu, Ruilin; Zhao, Chenxi; Wang, Jiao; Lu, Jiabin; Zhang, Bo; Lin, Nengming; Dong, Xin; Dai, Xiaoyang; Dong, Xiaowu; Yang, Bo; Zhu, Hong; He, Qiaojun.

Afiliação

Qian M; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yan F; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou 310058, China.
Wang W; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Du J; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yuan T; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Wu R; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhao C; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Wang J; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Lu J; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhang B; Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou 310006, China.
Lin N; Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou 310006, China.
Dong X; Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Dai X; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Dong X; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yang B; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhu H; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
He Q; Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Cancer Center, Zhejiang University School of Medicine, Hangzhou 310006, China.

Acta Pharm Sin B ; 11(12): 4008-4019, 2021 Dec.

Article em En | MEDLINE | ID: mdl-35024322

Palavras-chave

CCA, cholangiocarcinoma; Cholangiocarcinoma; DAB, 3,3-diaminobenzidine tetrahydrochloride chromogen; DUB, deubiquitinase; Deubiquitinase; FGFR, fibroblast growth factor receptor; FOLFOX, folinic acid, 5-FU and oxaliplatin; IDH1/2, isocitrate dehydrogenase 1/2; IHC, immunohistochemistry; IP, immunoprecipitation; JOSD2; KRAS, kirsten rat sarcoma 2 viral oncogene homolog; LATS1/2, large tumor suppressor kinase 1/2; MST1/2, mammalian Ste20-like kinases 1/2; OTUB2, otubain-2; PBS, phosphate-buffered saline; PDC, patient derived cell; PDX, patient-derived xenograft; RTV, relative tumor volume; SRB, sulforhodamine B; TAZ, transcriptional co-activator with PDZ-binding motif; TCGA, The Cancer Genome Atlas; USP9X/10/47, ubiquitin-specific peptidase 9X/10/47; YAP, Yes-associated protein; YAP/TAZ; YOD1, ubiquitin thioesterase OTU1; rhJOSD2, recombinant human JOSD2; shRNA, specific hairpin RNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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