Use of Arabinonucleosides for Development and Implementation of a Novel 2'-O-Protecting Group for Efficient Solid-Phase Synthesis and 2'-O-Deprotection of RNA Sequences.

Takahashi, Mayumi; Cawrse, Brian M; Grajkowski, Andrzej; Beaucage, Serge L

Takahashi, Mayumi; Cawrse, Brian M; Grajkowski, Andrzej; Beaucage, Serge L.

Afiliação

Takahashi M; Laboratory of Biological Chemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.
Cawrse BM; Laboratory of Biological Chemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.
Grajkowski A; Laboratory of Biological Chemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.
Beaucage SL; Laboratory of Biological Chemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.

Curr Protoc ; 2(1): e346, 2022 Jan.

Article em En | MEDLINE | ID: mdl-35030289

Assuntos

Ribonucleosídeos; Técnicas de Síntese em Fase Sólida; Arabinonucleosídeos; Sequência de Bases; Humanos; RNA

Palavras-chave

2'-O-imino-2-propanoic acid ethyl ester; arabinonucleosides; intramolecular decarboxylative 2Ê¹-O-deprotection; ribonucleoside-2Ê¹-O-protecting groups; solid-phase RNA synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleosídeos / Técnicas de Síntese em Fase Sólida Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Curr Protoc Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos

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