Syndecan-4 affects myogenesis via Rac1-mediated actin remodeling and exhibits copy-number amplification and increased expression in human rhabdomyosarcoma tumors.

Szabo, Kitti; Varga, Daniel; Vegh, Attila Gergely; Liu, Ning; Xiao, Xue; Xu, Lin; Dux, Laszlo; Erdelyi, Miklos; Rovo, Laszlo; Keller-Pinter, Aniko

Szabo, Kitti; Varga, Daniel; Vegh, Attila Gergely; Liu, Ning; Xiao, Xue; Xu, Lin; Dux, Laszlo; Erdelyi, Miklos; Rovo, Laszlo; Keller-Pinter, Aniko.

Afiliação

Szabo K; Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.
Varga D; Department of Optics and Quantum Electronics, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Vegh AG; Institute of Biophysics, Biological Research Centre, Eotvos Lorand Research Network (ELKH), Szeged, Hungary.
Liu N; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiao X; Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xu L; Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dux L; Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.
Erdelyi M; Department of Optics and Quantum Electronics, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Rovo L; Department of Oto-Rhino-Laryngology and Head- Neck Surgery, University of Szeged, Szeged, Hungary.
Keller-Pinter A; Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary. keller.aniko@med.u-szeged.hu.

Cell Mol Life Sci ; 79(2): 122, 2022 Feb 07.

Article em En | MEDLINE | ID: mdl-35128576

Assuntos

Actinas/metabolismo; Rabdomiossarcoma/patologia; Sindecana-4/metabolismo; Proteínas rac1 de Ligação ao GTP/metabolismo; Citoesqueleto de Actina; Animais; Diferenciação Celular; Linhagem Celular; Variações do Número de Cópias de DNA; Humanos; Masculino; Camundongos; Desenvolvimento Muscular; Músculo Esquelético/metabolismo; Mioblastos/citologia; Mioblastos/metabolismo; Interferência de RNA; RNA Interferente Pequeno/metabolismo; Ratos; Ratos Wistar; Rabdomiossarcoma/metabolismo; Sindecana-4/antagonistas & inibidores; Sindecana-4/genética; Proteína 1 Indutora de Invasão e Metástase de Linfoma de Células T/metabolismo

Palavras-chave

Actin; Atomic force microscopy; Muscle differentiation; Myoblast fusion; Proteoglycan; Rac1; Rhabdomyosarcoma; Syndecan-4; dSTORM superresolution microscopy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rabdomiossarcoma / Actinas / Proteínas rac1 de Ligação ao GTP / Sindecana-4 Limite: Animals / Humans / Male Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Hungria País de publicação: Suíça

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