Your browser doesn't support javascript.
loading
Associations between Gut Microbiota and Intestinal Inflammation, Permeability and Damage in Young Malawian Children.
Kortekangas, Emma; Fan, Yue-Mei; Chaima, David; Lehto, Kirsi-Maarit; Malamba-Banda, Chikondi; Matchado, Andrew; Chingwanda, Chilungamo; Liu, Zhifei; Ashorn, Ulla; Cheung, Yin Bun; Dewey, Kathryn G; Maleta, Kenneth; Ashorn, Per.
Afiliação
  • Kortekangas E; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
  • Fan YM; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
  • Chaima D; School of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Lehto KM; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
  • Malamba-Banda C; School of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Matchado A; School of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Chingwanda C; Department of Nutrition and Institute for Global Nutrition, University of California Davis, Davis, CA 95616, USA.
  • Liu Z; School of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Ashorn U; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
  • Cheung YB; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
  • Dewey KG; Program in Health Services & Systems Research and Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Maleta K; Department of Nutrition and Institute for Global Nutrition, University of California Davis, Davis, CA 95616, USA.
  • Ashorn P; School of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
J Trop Pediatr ; 68(2)2022 02 03.
Article em En | MEDLINE | ID: mdl-35149871
Chronic childhood undernutrition is an important public health concern that affects about 150 million children, mostly in low- and middle-income countries. Undernutrition is caused by insufficient nutrient intake and frequent infections, but there are also other underlying factors. One of these is a condition called environmental enteric dysfunction (EED), which is characterized by intestinal inflammation and damage without apparent clinical symptoms. EED is thought to be caused by the ingestion of pathogenic bacteria that leads to changes in the intestine such as increased permeability and decreased absorptive capacity. This might make the intestinal wall vulnerable to bacterial invasion and reduce the absorption of nutrients. Besides potentially pathogenic bacteria, there are many commensal bacteria in the gastrointestinal tract that have beneficial functions and that interact with the immune system. The aim of our study was to assess the associations between all these bacteria, that is the intestinal microbiota and biomarkers of EED. We used data from fecal samples collected from young children participating in a nutrition intervention trial in rural Malawi. Our findings support an inverse association between the diversity and maturity of the intestinal microbiota and biomarkers of EED. Additionally, we identified the differences at the level of individual bacterial taxa (groups of bacteria defined by genetic similarity) between participants with different levels of EED biomarkers. Due to the type of study, we cannot determine whether the observed associations represent a causal relationship between the intestinal microbiota and EED. This as well as the exact mechanisms behind these associations should be assessed in further studies.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: J Trop Pediatr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Finlândia País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Revista: J Trop Pediatr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Finlândia País de publicação: Reino Unido