Improving the cell-membrane-penetrating activity of globins by introducing positive charges on protein surface: A case study of sperm whale myoglobin.

Gao, Shu-Qin; Yuan, Hong; Yang, Xin-Zhi; Xiang, Heng-Fang; Tan, Xiangshi; Wen, Ge-Bo; Lin, Ying-Wu

Gao, Shu-Qin; Yuan, Hong; Yang, Xin-Zhi; Xiang, Heng-Fang; Tan, Xiangshi; Wen, Ge-Bo; Lin, Ying-Wu.

Afiliação

Gao SQ; Hengyang Medical School, University of South China, Hengyang, 421001, China.
Yuan H; Department of Chemistry & Institute of Biomedical Science, Fudan University, Shanghai, 200433, China.
Yang XZ; Hengyang Medical School, University of South China, Hengyang, 421001, China.
Xiang HF; Key Lab of Protein Structure and Function of Universities in Hunan Province, University of South China, Hengyang, 421001, China.
Tan X; Department of Chemistry & Institute of Biomedical Science, Fudan University, Shanghai, 200433, China.
Wen GB; Hengyang Medical School, University of South China, Hengyang, 421001, China; Key Lab of Protein Structure and Function of Universities in Hunan Province, University of South China, Hengyang, 421001, China. Electronic address: wengebo@usc.edu.cn.
Lin YW; Hengyang Medical School, University of South China, Hengyang, 421001, China; Key Lab of Protein Structure and Function of Universities in Hunan Province, University of South China, Hengyang, 421001, China. Electronic address: ywlin@usc.edu.cn.

Biochem Biophys Res Commun ; 598: 26-31, 2022 04 02.

Article em En | MEDLINE | ID: mdl-35151200

Assuntos

Membrana Celular/metabolismo; Mioglobina/química; Mioglobina/metabolismo; Animais; Membrana Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Dicroísmo Circular; Cristalografia por Raios X; Fluoresceína-5-Isotiocianato/química; Humanos; Lisina/química; Células MCF-7; Mutação; Mioglobina/genética; Mioglobina/farmacocinética; Espectrofotometria Ultravioleta; Cachalote

Palavras-chave

Cell membrane; Globins; Heme proteins; Protein transduction; X-ray crystallography

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Celular / Mioglobina Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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