Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells.

Zhang, Lingling; Liang, Bing; Xu, Huan; Gong, Yanju; Hu, Wangming; Jin, Zhong; Wu, Xiao; Chen, Xiongbin; Li, Min; Shi, Liangqin; Shi, Yaping; Wang, Yong; Yang, Lan

Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells.

Zhang, Lingling; Liang, Bing; Xu, Huan; Gong, Yanju; Hu, Wangming; Jin, Zhong; Wu, Xiao; Chen, Xiongbin; Li, Min; Shi, Liangqin; Shi, Yaping; Wang, Yong; Yang, Lan.

Afiliação

Zhang L; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Liang B; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xu H; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Gong Y; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hu W; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Jin Z; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Wu X; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chen X; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Li M; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Shi L; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Shi Y; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Wang Y; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China. Electronic address: wangyong@cdutcm.edu.cn.
Yang L; Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China. Electronic address: yanglan@cdutcm.edu.cn.

J Ethnopharmacol ; 291: 115095, 2022 Jun 12.

Article em En | MEDLINE | ID: mdl-35176466

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Células A549; Animais; Apoptose; Bufanolídeos; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Proteína Forkhead Box O1/genética; Proteína Forkhead Box O1/metabolismo; Proteína Forkhead Box O1/farmacologia; Regulação Neoplásica da Expressão Gênica; Antígenos de Histocompatibilidade/genética; Antígenos de Histocompatibilidade/metabolismo; Antígenos de Histocompatibilidade/farmacologia; Histona-Lisina N-Metiltransferase/genética; Histona-Lisina N-Metiltransferase/metabolismo; Humanos; Neoplasias Pulmonares/metabolismo; Camundongos

Palavras-chave

Apoptosis; Cinobufagin(CNB); Euchromatic histone-lysine N-methyltransferase 2(G9a,EHMT2); Forkhead box O1(FOXO1); Non-small-cell lung cancer (NSCLC)

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Irlanda

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google