Age-specific effectiveness of a tuberculosis screening intervention in children.
PLoS One
; 17(2): e0264216, 2022.
Article
em En
| MEDLINE
| ID: mdl-35180263
ABSTRACT
OBJECTIVE:
To apply a cascade-of-care framework to evaluate the effectiveness-by age of the child-of an intensified tuberculosis patient-finding intervention.DESIGN:
From a prospective screening program at four hospitals in Pakistan (2014-2016) we constructed a care cascade comprising sixsteps:
screened, positive screen, evaluated, diagnosed, started treatment, and successful outcome. We evaluated the cascade by each year of age from 0 to 14 and report the age-specific mean proportion and standard deviation.RESULTS:
On average across all ages, only 12.5% (standard deviation 2.0%) of children with a positive screen were not evaluated. Among children who had a complete evaluation, the highest percentages of children diagnosed with tuberculosis were observed in children 0-4 (mean 31.9%; standard deviation 4.8%), followed by lower percentages in children 5-9 (mean 22.4%; standard deviation 2.2%), and 10-14 (mean 26.0%; standard deviation5.4%). Nearly all children diagnosed with tuberculosis initiated treatment, and an average of 93.3% (standard deviation 3.3%) across all ages had successful treatment outcomes.CONCLUSIONS:
This intervention was highly effective across ages 0-14 years. Our study illustrates the utility of applying operational analyses of age-stratified cascades to identify age-specific gaps in pediatric tuberculosis care that can guide future, novel interventions to close these gaps.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Programas de Rastreamento
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos