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Increased amplitude of hippocampal low frequency fluctuations in early psychosis: A two-year follow-up study.
McHugo, Maureen; Rogers, Baxter P; Avery, Suzanne N; Armstrong, Kristan; Blackford, Jennifer Urbano; Vandekar, Simon N; Roeske, Maxwell J; Woodward, Neil D; Heckers, Stephan.
Afiliação
  • McHugo M; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: maureen.mchugo@vanderbilt.edu.
  • Rogers BP; Vanderbilt University Institute of Imaging Sciences, Nashville, TN, USA.
  • Avery SN; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Armstrong K; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Blackford JU; Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
  • Vandekar SN; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Roeske MJ; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Woodward ND; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Heckers S; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Schizophr Res ; 241: 260-266, 2022 03.
Article em En | MEDLINE | ID: mdl-35180665
ABSTRACT
Neuroimaging studies have revealed hippocampal hyperactivity in schizophrenia. In the early stage of the illness, hyperactivity is present in the anterior hippocampus and is thought to spread to other regions as the illness progresses. However, there is limited evidence for changes in basal hippocampal function following the onset of psychosis. Resting state functional MRI signal amplitude may be a proxy measure for increased metabolism and disrupted oscillatory activity, both consequences of an excitation/inhibition imbalance underlying hippocampal hyperactivity. Here, we used fractional amplitude of low frequency fluctuations (fALFF) to test the hypothesis of progressive hippocampal hyperactivity in a two-year longitudinal case-control study. We found higher fALFF in the anterior and posterior hippocampus of individuals in the early stage of non-affective psychosis at study entry. Contrary to our hypothesis of progressive hippocampal dysfunction, we found evidence for normalization of fALFF over time in psychosis. Our findings support a model in which hippocampal fALFF is a marker of psychosis vulnerability or acute illness state rather than an enduring feature of the illness.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Schizophr Res Assunto da revista: PSIQUIATRIA Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Schizophr Res Assunto da revista: PSIQUIATRIA Ano de publicação: 2022 Tipo de documento: Article