Autophagy system as a potential therapeutic target for neurodegenerative diseases.
Neurochem Int
; 155: 105308, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-35181396
ABSTRACT
Autophagy is an evolutionally conserved process by which cytoplasmic contents including protein aggregates and damaged organelles such as mitochondria and lysosomes, are sequestered by double-membrane structure, autophagosomes, and delivered to the lysosomes for degradation. Recently, considerable efforts have been made to reveal the role of autophagy in neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease. Impairment of autophagy aggravates the accumulation of misfolded protein and damaged organelles in neurons, while sufficient autophagic activity reduces such accumulation in nervous system and ameliorates the pathology. Here we summarize recent progress regarding the role of autophagy in several neurodegenerative diseases and the potential autophagy-associated therapies for them.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Huntington
/
Doenças Neurodegenerativas
Limite:
Humans
Idioma:
En
Revista:
Neurochem Int
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Japão