Exosomes derived from bone mesenchymal stem cells attenuate myocardial fibrosis both in vivo and in vitro via autophagy activation: the key role of miR-199a-3p/mTOR pathway.

Fan, Chenrong; Wang, Qizeng; Chen, Youjin; Ye, Tingting; Fan, Yuncao

Fan, Chenrong; Wang, Qizeng; Chen, Youjin; Ye, Tingting; Fan, Yuncao.

Afiliação

Fan C; Department of Cardiology, The First People's Hospital of Wenling, No. 333 Chuan'an South Road, Chengxi Street, Wenling, 317500, Zhejiang, China.
Wang Q; Department of Cardiology, The First People's Hospital of Wenling, No. 333 Chuan'an South Road, Chengxi Street, Wenling, 317500, Zhejiang, China.
Chen Y; Department of Cardiology, The First People's Hospital of Wenling, No. 333 Chuan'an South Road, Chengxi Street, Wenling, 317500, Zhejiang, China.
Ye T; Department of Cardiology, The First People's Hospital of Wenling, No. 333 Chuan'an South Road, Chengxi Street, Wenling, 317500, Zhejiang, China.
Fan Y; Department of Cardiology, The First People's Hospital of Wenling, No. 333 Chuan'an South Road, Chengxi Street, Wenling, 317500, Zhejiang, China. ycfan_peson1988@outlook.com.

Hum Cell ; 35(3): 817-835, 2022 May.

Article em En | MEDLINE | ID: mdl-35190954

Assuntos

Exossomos; Células-Tronco Mesenquimais; MicroRNAs; Animais; Autofagia/genética; Exossomos/genética; Exossomos/metabolismo; Fibrose; MicroRNAs/genética; MicroRNAs/metabolismo; Ratos; Serina-Treonina Quinases TOR/genética; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

Autophagy; Bone mesenchymal stem cell; Exosome; Myocardial fibrosis; mTOR; miR-199a-3p

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Exossomos / Células-Tronco Mesenquimais Limite: Animals Idioma: En Revista: Hum Cell Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Japão

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