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A single nonsynonymous mutation on ZIKV E protein-coding sequences leads to markedly increased neurovirulence in vivo.
Liu, Zhihua; Zhang, Yawei; Cheng, Mengli; Ge, Ningning; Shu, Jiayi; Xu, Zhiheng; Su, Xiao; Kou, Zhihua; Tong, Yigang; Qin, Chengfeng; Jin, Xia.
Afiliação
  • Liu Z; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Vaccine and Immunology Research Center, Translational Medical Research Institute, Shanghai Public Health Clinical Center, Fudan University, Shanghai,
  • Zhang Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.
  • Cheng M; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.
  • Ge N; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Vaccine and Immunology Research Center, Translational Medical Research Institute, Shanghai Public Health Clinical Center, Fudan University, Shanghai,
  • Shu J; Vaccine and Immunology Research Center, Translational Medical Research Institute, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
  • Xu Z; State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Su X; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Kou Z; Vaccine and Immunology Research Center, Translational Medical Research Institute, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China. Electronic address: kouzhihua@shphc.org.cn.
  • Tong Y; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China. Electronic address: tong.yigang@gmail.com.
  • Qin C; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. Electronic address: qincf@bmi.ac.cn.
  • Jin X; Vaccine and Immunology Research Center, Translational Medical Research Institute, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China. Electronic address: jinxia@shphc.org.cn.
Virol Sin ; 37(1): 115-126, 2022 Feb.
Article em En | MEDLINE | ID: mdl-35234632
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zika virus / Infecção por Zika virus Limite: Animals / Humans Idioma: En Revista: Virol Sin Assunto da revista: VIROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zika virus / Infecção por Zika virus Limite: Animals / Humans Idioma: En Revista: Virol Sin Assunto da revista: VIROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda