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Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia.
Krajner, Fanni; Hadaya, Laila; McQueen, Grant; Sendt, Kyra-Verena; Gillespie, Amy; Avila, Alessia; Lally, John; Hedges, Emily P; Diederen, Kelly; Howes, Oliver D; Barker, Gareth J; Lythgoe, David J; Kempton, Matthew J; McGuire, Philip; MacCabe, James H; Egerton, Alice.
Afiliação
  • Krajner F; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Hadaya L; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • McQueen G; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Sendt KV; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Gillespie A; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Avila A; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
  • Lally J; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Hedges EP; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Diederen K; Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Howes OD; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Barker GJ; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Lythgoe DJ; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Kempton MJ; South London and Maudsley NHS Trust, London, UK.
  • McGuire P; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • MacCabe JH; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
  • Egerton A; Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, London, UK.
Schizophrenia (Heidelb) ; 8(1): 13, 2022 03 02.
Article em En | MEDLINE | ID: mdl-35236831
ABSTRACT
The neurobiological effects of clozapine are under characterised. We examined the effects clozapine treatment on subcortical volume and cortical thickness and investigated whether macrostructural changes were linked to alterations in glutamate or N-acetylaspartate (NAA). Data were acquired in 24 patients with treatment-resistant schizophrenia before and 12 weeks after switching to clozapine. During clozapine treatment we observed reductions in caudate and putamen volume, lateral ventricle enlargement (P < 0.001), and reductions in thickness of the left inferior temporal cortex, left caudal middle frontal cortex, and the right temporal pole. Reductions in right caudate volume were associated with local reductions in NAA (P = 0.002). None of the morphometric changes were associated with changes in glutamate levels. These results indicate that clozapine treatment is associated with subcortical volume loss and cortical thinning and that at least some of these effects are linked to changes in neuronal or metabolic integrity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Schizophrenia (Heidelb) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Schizophrenia (Heidelb) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido