Water based-deep eutectic solvent for ultrasound-assisted liquid-liquid microextraction of parabens in edible oil.

A novel water-based deep eutectic solvent was synthesized and used for the ultrasound-assisted liquid-liquid microextraction of parabens in edible oil and for their determination by high performance liquid chromatography. Herein, the water-based deep eutectic solvent was formulated at room temperature by tetrabutylammonium chloride as hydrogen bond acceptor and water as hydrogen bond donor at the molar ratio of 1:5. As component, water has the effect on tailoring the physicochemical properties of water-based deep eutectic solvent and assisting tetrabutylammonium chloride (hydrogen bond acceptor) capturing parabens (hydrogen bond donor) through in-situ deep eutectic solvent formation. The developed method has satisfactory linearity (1.5-500 µg/L), limits of detections (0.2-0.4 µg/L), precisions (RSDs ≤ 5.8%), and was fruitfully applied to detect parabens in edible oil with excellent recoveries (85.1-106.8%). The feature of the procedure lies in simplicity, low cost and high sensitivity, and this can be extended for the efficient separation of other hydrophobic compounds.