Stable isotopes in pharmacology studies: present and future.
J Clin Pharmacol
; 26(6): 485-9, 1986.
Article
em En
| MEDLINE
| ID: mdl-3525614
ABSTRACT
Stable-isotope techniques offer advantages over older methods in safety, sensitivity, specificity, and reduction in numbers of subjects required and analytic determinations for some types of pharmacology studies. In addition to their use as internal standards in gas chromatography-mass spectrometry analytic methods, stable isotopes have been successfully employed in studies of absorption, bioavailability, distribution, biotransformation, excretion, metabolite identification, time-dependent and dose-dependent pharmacokinetic changes, drug interactions, pharmacologic changes during pregnancy, mutagenicity, and teratogenicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Farmacologia
/
Isótopos
Limite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Clin Pharmacol
Ano de publicação:
1986
Tipo de documento:
Article