Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high-molecular weight complexes.

Daude, Nathalie; Lau, Agnes; Vanni, Ilaria; Kang, Sang-Gyun; Castle, Andrew R; Wohlgemuth, Serene; Dorosh, Lyudmyla; Wille, Holger; Stepanova, Maria; Westaway, David

Daude, Nathalie; Lau, Agnes; Vanni, Ilaria; Kang, Sang-Gyun; Castle, Andrew R; Wohlgemuth, Serene; Dorosh, Lyudmyla; Wille, Holger; Stepanova, Maria; Westaway, David.

Afiliação

Daude N; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Lau A; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Vanni I; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Kang SG; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Castle AR; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Wohlgemuth S; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Dorosh L; Faculty of Engineering - Electrical & Computer Engineering Department, University of Alberta, Edmonton, Canada.
Wille H; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada; Department of Biochemistry, University of Alberta, Edmonton, Canada.
Stepanova M; Faculty of Engineering - Electrical & Computer Engineering Department, University of Alberta, Edmonton, Canada.
Westaway D; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada. Electronic address: david.westaway@ualberta.ca.

J Biol Chem ; 298(4): 101770, 2022 04.

Article em En | MEDLINE | ID: mdl-35271850

Assuntos

Doenças Priônicas; Proteínas Priônicas; Príons; Animais; Cobre/metabolismo; Peso Molecular; Mutação; Doenças Priônicas/genética; Doenças Priônicas/fisiopatologia; Proteínas Priônicas/química; Proteínas Priônicas/genética; Príons/genética; Príons/metabolismo; Príons/patogenicidade; Ligação Proteica/genética; Vitamina B 12/metabolismo

Palavras-chave

cobalamin; conformational change; glycoprotein; oligomer; plasma membrane; prion; sporadic disease; vitamin B12

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Príons / Doenças Priônicas / Proteínas Priônicas Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos

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