Pentosan polysulfate ameliorates fibrosis and inflammation markers in SV40 MES13 cells by suppressing activation of PI3K/AKT pathway via miR-446a-3p.

Xiao, Liangxiang; Chen, Anqun; Gao, Qing; Xu, Bo; Guo, Xiaodan; Guan, Tianjun

Xiao, Liangxiang; Chen, Anqun; Gao, Qing; Xu, Bo; Guo, Xiaodan; Guan, Tianjun.

Afiliação

Xiao L; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Chen A; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Gao Q; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Xu B; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Guo X; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China.
Guan T; Department of Nephrology, Zhongshan Hospital of Xiamen University, School of Medicine, Xamen University, No 203, Hubin South Road, Siming district, Xiamen, 361004, Fujian, China. tianjunguan@aliyun.com.

BMC Nephrol ; 23(1): 105, 2022 03 15.

Article em En | MEDLINE | ID: mdl-35291969

Assuntos

Nefropatias Diabéticas; MicroRNAs; Animais; Biomarcadores; Nefropatias Diabéticas/patologia; Fibrose; Inflamação/complicações; Inflamação/tratamento farmacológico; Interleucina-6; Camundongos; MicroRNAs/genética; Poliéster Sulfúrico de Pentosana/farmacologia; Fosfatidilinositol 3-Quinase; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Advanced glycation end products; Diabetic nephrology; Pentosan polysulphate sodium; Renal fibrosis; microRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Nefropatias Diabéticas Limite: Animals Idioma: En Revista: BMC Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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