Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity.

LeBlanc, Véronique G; Trinh, Diane L; Aslanpour, Shaghayegh; Hughes, Martha; Livingstone, Dorothea; Jin, Dan; Ahn, Bo Young; Blough, Michael D; Cairncross, J Gregory; Chan, Jennifer A; Kelly, John J P; Marra, Marco A

LeBlanc, Véronique G; Trinh, Diane L; Aslanpour, Shaghayegh; Hughes, Martha; Livingstone, Dorothea; Jin, Dan; Ahn, Bo Young; Blough, Michael D; Cairncross, J Gregory; Chan, Jennifer A; Kelly, John J P; Marra, Marco A.

Afiliação

LeBlanc VG; Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, V5Z 4S6 BC, Canada.
Trinh DL; Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, V5Z 4S6 BC, Canada.
Aslanpour S; Department of Clinical Neurosciences, University of Calgary, Calgary, T2N 2T9 AB, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, T2N 4Z6 AB, Canada.
Hughes M; Department of Clinical Neurosciences, University of Calgary, Calgary, T2N 2T9 AB, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, T2N 4Z6 AB, Canada.
Livingstone D; Department of Clinical Neurosciences, University of Calgary, Calgary, T2N 2T9 AB, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, T2N 4Z6 AB, Canada.
Jin D; Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, V5Z 4S6 BC, Canada.
Ahn BY; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, T2N 4Z6 AB, Canada.
Blough MD; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, T2N 4Z6 AB, Canada.
Cairncross JG; Department of Clinical Neurosciences, University of Calgary, Calgary, T2N 2T9 AB, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, T2N 4Z6 AB, Canada.
Chan JA; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, T2N 4Z6 AB, Canada; Department of Pathology & Laboratory Medicine, University of Calgary, Calgary, T2L 2K8 AB, Canada.
Kelly JJP; Department of Clinical Neurosciences, University of Calgary, Calgary, T2N 2T9 AB, Canada; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, T2N 4Z6 AB, Canada.
Marra MA; Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, V5Z 4S6 BC, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, V6H 3N1 BC, Canada. Electronic address: mmarra@bcgsc.ca.

Cancer Cell ; 40(4): 379-392.e9, 2022 04 11.

Article em En | MEDLINE | ID: mdl-35303420

Assuntos

Neoplasias Encefálicas; Glioblastoma; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/patologia; Linhagem Celular; Genômica; Glioblastoma/genética; Glioblastoma/patologia; Humanos; Recidiva Local de Neoplasia

Palavras-chave

3D models; explant; glioblastoma; gliomasphere; patient-derived models; single-cell RNA-seq; single-cell genome sequencing; single-cell genomics; whole-exome sequencing

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google