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Immune checkpoint inhibitor-induced myocarditis, myositis, myasthenia gravis and transaminitis: a case series and review.
Wai Siu, Derrick Ho; O'Neill, Robert Sean; Harris, Carole A; Wang, Justine; Ardolino, Luke; Downton, Teesha; Tong, Matthew; Hong, Jun Hee; Chin, Venessa; Clingan, Philip R; Aghmesheh, Morteza; Soudy, Hussein.
Afiliação
  • Wai Siu DH; Department of Medical Oncology, St George Hospital, Kogarah, New South Wales, 2217, Australia.
  • O'Neill RS; National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, 2050, Australia.
  • Harris CA; Faculty of Medicine, The University of New South Wales, New South Wales, Australia.
  • Wang J; Faculty of Medicine, The University of New South Wales, New South Wales, Australia.
  • Ardolino L; Department of Medical Oncology, Sutherland Hospital, Caringbah, New South Wales, 2229, Australia.
  • Downton T; Department of Medical Oncology, St George Hospital, Kogarah, New South Wales, 2217, Australia.
  • Tong M; Faculty of Medicine, The University of New South Wales, New South Wales, Australia.
  • Hong JH; Department of Medical Oncology, Sutherland Hospital, Caringbah, New South Wales, 2229, Australia.
  • Chin V; Faculty of Medicine, The University of New South Wales, New South Wales, Australia.
  • Clingan PR; Department of Neurology, St George Hospital, Kogarah, New South Wales, 2217, Australia.
  • Aghmesheh M; Institute of Neurological Sciences, Prince of Wales Hospital, Randwick, New South Wales, 2031, Australia.
  • Soudy H; Faculty of Medicine, The University of New South Wales, New South Wales, Australia.
Immunotherapy ; 14(7): 511-520, 2022 05.
Article em En | MEDLINE | ID: mdl-35321560
Cancer immunotherapy is used in the treatment of different cancer types. Immunotherapy activates the immune system to detect and attack cancer cells, but side effects may arise from the immune system inadvertently attacking normal tissues and organs. The increased use of immunotherapy has led to an increase in the reporting of rare but potentially life-threatening treatment-related side effects. In this case series, the authors report the clinical features and outcomes of seven patients who developed inflammation of the heart, muscles, nerve and muscle junctions and liver following treatment with immunotherapy. The authors review the scientific literature and discuss the current understanding of and management approach to this rare syndrome. The authors' report highlights the importance of a high degree of clinical suspicion, prompt comprehensive testing to confirm diagnosis, early involvement of experts from different specialties and early initiation of treatment in the management of this unique syndrome.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miastenia Gravis / Miocardite / Miosite / Neoplasias Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Immunotherapy Assunto da revista: ALERGIA E IMUNOLOGIA / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miastenia Gravis / Miocardite / Miosite / Neoplasias Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Immunotherapy Assunto da revista: ALERGIA E IMUNOLOGIA / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália País de publicação: Reino Unido