Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous Conus distans.
Toxins (Basel)
; 14(3)2022 03 19.
Article
em En
| MEDLINE
| ID: mdl-35324723
ABSTRACT
The defensive use of cone snail venom is hypothesised to have first arisen in ancestral worm-hunting snails and later repurposed in a compartmentalised venom duct to facilitate the dietary shift to molluscivory and piscivory. Consistent with its placement in a basal lineage, we demonstrate that the C. distans venom gland lacked distinct compartmentalisation. Transcriptomics revealed C. distans expressed a wide range of structural classes, with inhibitory cysteine knot (ICK)-containing peptides dominating. To better understand the evolution of the venom gland compartmentalisation, we compared C. distans to C. planorbis, the earliest diverging species from which a defence-evoked venom has been obtained, and fish-hunting C. geographus from the Gastridium subgenus that injects distinct defensive and predatory venoms. These comparisons support the hypothesis that venom gland compartmentalisation arose in worm-hunting species and enabled repurposing of venom peptides to facilitate the dietary shift from vermivory to molluscivory and piscivory in more recently diverged cone snail lineages.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Conotoxinas
/
Caramujo Conus
Limite:
Animals
Idioma:
En
Revista:
Toxins (Basel)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Austrália