Factors affecting minimal manifestation status induction in myasthenia gravis.
Ther Adv Neurol Disord
; 15: 17562864221080520, 2022.
Article
em En
| MEDLINE
| ID: mdl-35371293
ABSTRACT
Background:
Minimal manifestation status (MMS) is an important landmark in the treatment of myasthenia gravis (MG), and predictors of MMS induction have rarely been identified in previous studies.Objective:
The objective of this study is to evaluate the clinical factors associated with MMS induction among patients with MG.Design:
This two-step retrospective cohort study with a single center investigated the factors that may be associated with MMS induction and retested these predictors in a test cohort.Methods:
A total of 388 diagnosed MG patients who visited Xiangya Hospital between 1 July 2015 and 1 July 2019 were involved. We performed detailed chart reviews and recorded all cases achieving MMS. Demographics and clinical characteristics were also collected and their relationships to achieving MMS were investigated.Results:
MMS was achieved in 124 patients (50.2%), and the median time to achieve MMS was 26 months. Several factors were found to be associated with MMS induction in exploring cohort, including muscle-specific tyrosine-protein kinase receptor (MuSK) antibody positivity (adjusted hazard ratio, HRâ=â4.333, 95% confidence interval, CI 1.862-10.082), isolated ocular involvement (adjusted HRâ=â1.95, 95% CI 1.284-2.961), and low baseline quantitative myasthenia gravis score (QMG score; adjusted HRâ=â2.022, 95% CI 1.086-3.764). These factors were then retested in the test cohort. Isolated ocular involvement or low baseline QMG scores were factors found to be beneficial for MMS induction were confirmed.Conclusion:
Isolated ocular involvement and low baseline QMG score are predictors of MMS induction in MG patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Ther Adv Neurol Disord
Ano de publicação:
2022
Tipo de documento:
Article