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Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development.
Charlton, Sacha N; Hayes, Martin A.
Afiliação
  • Charlton SN; School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
  • Hayes MA; Compound Synthesis and Management, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
ChemMedChem ; 17(12): e202200115, 2022 06 20.
Article em En | MEDLINE | ID: mdl-35385205
C-H oxyfunctionalisation remains a distinct challenge for synthetic organic chemists. Oxygenases and peroxygenases (grouped here as "oxygenating biocatalysts") catalyse the oxidation of a substrate with molecular oxygen or hydrogen peroxide as oxidant. The application of oxygenating biocatalysts in organic synthesis has dramatically increased over the last decade, producing complex compounds with potential uses in the pharmaceutical industry. This review will focus on hydroxyl functionalisation using oxygenating biocatalysts as a tool for drug discovery and development. Established oxygenating biocatalysts, such as cytochrome P450s and flavin-dependent monooxygenases, have widely been adopted for this purpose, but can suffer from low activity, instability or limited substrate scope. Therefore, emerging oxygenating biocatalysts which offer an alternative will also be covered, as well as considering the ways in which these hydroxylation biotransformations can be applied in drug discovery and development, such as late-stage functionalisation (LSF) and in biocatalytic cascades.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Enzimático do Citocromo P-450 / Descoberta de Drogas Idioma: En Revista: ChemMedChem Assunto da revista: FARMACOLOGIA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistema Enzimático do Citocromo P-450 / Descoberta de Drogas Idioma: En Revista: ChemMedChem Assunto da revista: FARMACOLOGIA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Alemanha