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HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission.
Koole, Jeffrey Cd; de la Court, Feline; Welkers, Matthijs Ra; Yap, Kenneth; Stalenhoef, Janneke E; Jurriaans, Suzanne; de Vries, Henry Jc; Op de Coul, Eline Lm; Prins, Maria; Hoornenborg, Elske.
Afiliação
  • Koole JC; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.
  • de la Court F; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.
  • Welkers MR; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.
  • Yap K; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam, the Netherlands.
  • Stalenhoef JE; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.
  • Jurriaans S; Department of Internal Medicine, OLVG, Amsterdam, the Netherlands.
  • de Vries HJ; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam, the Netherlands.
  • Op de Coul EL; Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.
  • Prins M; Department of Dermatology, Amsterdam Institute for Infection and Immunity (AII), Amsterdam UMC, University of Amsterdam, location Academic Medical Centre, Amsterdam, the Netherlands.
  • Hoornenborg E; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Euro Surveill ; 27(14)2022 04.
Article em En | MEDLINE | ID: mdl-35393931
In August 2021, a man who has sex with men was diagnosed with HIV-1 infection despite using event-driven pre-exposure prophylaxis for over 2 years with self-reported excellent adherence. Sequencing identified resistance-associated mutations (RAM) M184V and K65R, conferring resistance to emtricitabine and tenofovir, and RAM V108I and E138A. Background RAM prevalence was two of 164 (1.2%) new HIV diagnoses in Amsterdam (2017-19). We reiterate the need for frequent HIV testing among PrEP users and additional testing in case of symptoms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Fármacos Anti-HIV / Profilaxia Pré-Exposição / Minorias Sexuais e de Gênero Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male País/Região como assunto: Europa Idioma: En Revista: Euro Surveill Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda País de publicação: Suécia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Fármacos Anti-HIV / Profilaxia Pré-Exposição / Minorias Sexuais e de Gênero Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male País/Região como assunto: Europa Idioma: En Revista: Euro Surveill Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda País de publicação: Suécia