Breakage in breakage-fusion-bridge cycle: an 80-year-old mystery.

Guérin, Thomas M; Marcand, Stéphane

Guérin, Thomas M; Marcand, Stéphane.

Afiliação

Guérin TM; Université Paris-Saclay, Université de Paris, Inserm, CEA, Institut de Biologie François Jacob, iRCM, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France; Current address: Chromosome Segregation Laboratory, The Francis Crick Institute, London, UK.
Marcand S; Université Paris-Saclay, Université de Paris, Inserm, CEA, Institut de Biologie François Jacob, iRCM, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France. Electronic address: stephane.marcand@cea.fr.

Trends Genet ; 38(7): 641-645, 2022 07.

Article em En | MEDLINE | ID: mdl-35397934

RESUMO

2021 marked the 80th anniversary of Barbara McClintock's pioneering article on the breakage-fusion-bridge (BFB) cycle. Of the three steps of the BFB cycle, breakage remains the least understood despite its major contribution to mutagenesis. We discuss recent findings shedding light on how chromatin bridges break in yeast and animal cells.

Assuntos

Ciclo Celular/genética; Cromossomos; Citogenética/história; Saccharomyces cerevisiae; Instabilidade Genômica; História do Século XX; Saccharomyces cerevisiae/genética; Telômero

Palavras-chave

chromosome; cytokinesis; dicentric; genome instability; oncogenesis; telomere

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Ciclo Celular / Cromossomos / Citogenética Idioma: En Revista: Trends Genet Assunto da revista: GENETICA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Reino Unido

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