Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.
JACC Basic Transl Sci
; 7(3): 265-293, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-35411324
ABSTRACT
This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.
ACE, angiotensin-converting enzyme; AD, autonomic dysregulation; AF, atrial fibrillation; ANS, autonomic nervous system; Ach, acetylcholine; CNS, central nervous system; COPD, chronic obstructive pulmonary disease; CSA, central sleep apnea; CVD, cardiovascular disease; ECG, electrocardiogram; EV, extracellular vesicle; GP, ganglionated plexi; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; HRV, heart rate variability; LQT, long QT; MI, myocardial infarction; NE, norepinephrine; NHLBI, National Heart, Lung, and Blood Institute; NPY, neuropeptide Y; NREM, non-rapid eye movement; OSA, obstructive sleep apnea; PAH, pulmonary arterial hypertension; PV, pulmonary vein; REM, rapid eye movement; RV, right ventricular; SCD, sudden cardiac death; SDB, sleep disordered breathing; SNA, sympathetic nerve activity; SNSA, sympathetic nervous system activity; TLD, targeted lung denervation; asthma; atrial fibrillation; autonomic nervous system; cardiopulmonary; chronic obstructive pulmonary disease; circadian; heart failure; pulmonary arterial hypertension; sleep apnea; ventricular arrhythmia
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
JACC Basic Transl Sci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos