Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes.

Uehara, Shotaro; Murayama, Norie; Higuchi, Yuichiro; Yoneda, Nao; Yamazaki, Hiroshi; Suemizu, Hiroshi

Uehara, Shotaro; Murayama, Norie; Higuchi, Yuichiro; Yoneda, Nao; Yamazaki, Hiroshi; Suemizu, Hiroshi.

Afiliação

Uehara S; Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan.
Murayama N; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan.
Higuchi Y; Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan.
Yoneda N; Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan.
Suemizu H; Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan.

Xenobiotica ; 52(3): 229-239, 2022 Mar.

Article em En | MEDLINE | ID: mdl-35416115

Assuntos

Sistema Enzimático do Citocromo P-450; Microssomos Hepáticos; Clorzoxazona/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Humanos; Fígado/metabolismo; Mefenitoína/metabolismo; Microssomos/metabolismo; Microssomos Hepáticos/metabolismo

Palavras-chave

7-pentoxyresorufin; Cytochrome P450; bufuralol; diazepam; drug oxidation; hepatic and extrahepatic tissues; propafenone; species differences

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Sistema Enzimático do Citocromo P-450 Limite: Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido

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