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Modelling the impact of antimicrobial use and external introductions on commensal E. coli colistin resistance in small-scale chicken farms of the Mekong delta of Vietnam.
Bastard, Jonathan; Nhung, Nguyen Thi; Hien, Vo Be; Kiet, Bach Tuan; Temime, Laura; Opatowski, Lulla; Carrique-Mas, Juan; Choisy, Marc.
Afiliação
  • Bastard J; Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, CESP, Anti-Infective Evasion and Pharmacoepidemiology Team, Montigny-le-Bretonneux, France.
  • Nhung NT; Institut Pasteur, Epidemiology and Modelling of Antibiotic Evasion Unit, Paris, France.
  • Hien VB; MESuRS laboratory, Conservatoire national des arts et métiers, Paris, France.
  • Kiet BT; PACRI unit, Institut Pasteur, Conservatoire national des arts et métiers, Paris, France.
  • Temime L; Oxford University Clinical Research Unit, Ho Chi Minh, Vietnam.
  • Opatowski L; Sub-Department of Animal Health and Production, Dong Thap, Vietnam.
  • Carrique-Mas J; Sub-Department of Animal Health and Production, Dong Thap, Vietnam.
  • Choisy M; MESuRS laboratory, Conservatoire national des arts et métiers, Paris, France.
Transbound Emerg Dis ; 69(5): e2185-e2194, 2022 Sep.
Article em En | MEDLINE | ID: mdl-35419995
Colistin is a critically important antimicrobial for human medicine, and colistin-resistant Escherichia coli are commonly found in poultry and poultry products in Southeast Asia. Here, we aim at disentangling the within-farm and outside-farm drivers of colistin resistance in small-scale chicken farms of the Mekong delta of Vietnam. Nineteen Vietnamese chicken farms were followed up along a whole production cycle, during which weekly antimicrobial use data were recorded. At the beginning, middle and end of each production cycle, commensal E. coli samples from birds were collected, pooled and tested for colistin resistance. Twelve models were fitted to the data using an expectation-maximization algorithm and compared. We further tested the spatial clustering of the occurrence of resistance importations from external sources using the local Moran's I statistic. In the best model, colistin resistance in E. coli from chickens was found to be mostly affected by importations of resistance, and, to a lesser extent, by the use of antimicrobials in the last 1.73 weeks [0.00; 2.90], but not by the use of antimicrobials in day-olds, nor their colistin resistance carriage from hatchery. The occurrence of external source importations proved to be sometimes spatially clustered, suggesting a role of local environmental sources of colistin resistance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colistina / Anti-Infecciosos Limite: Animals / Humans País/Região como assunto: Asia Idioma: En Revista: Transbound Emerg Dis Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colistina / Anti-Infecciosos Limite: Animals / Humans País/Região como assunto: Asia Idioma: En Revista: Transbound Emerg Dis Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França País de publicação: Alemanha