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Electrogenerated chemiluminescence of a Ru(bpy)3 2+/arginine system: a specific and sensitive detection of acetaminophen.
Xiao, Yi; Wang, Guofang; Yi, Haomin; Chen, Suhua; Wu, Qinyu; Zhang, Siyi; Deng, Kexin; Zhang, Simeng; Shi, Zi-Qi; Yang, Xiaoping.
Afiliação
  • Xiao Y; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University Changsha 410013 Hunan China Xiaoping.Yang@hunnu.edu.cn shiziqi47@126.com.
  • Wang G; John A. Paulson School of Engineering and Applied Sciences, Harvard University Cambridge MA 02138 USA.
  • Yi H; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University Changsha 410013 Hunan China Xiaoping.Yang@hunnu.edu.cn shiziqi47@126.com.
  • Chen S; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University Changsha 410013 Hunan China Xiaoping.Yang@hunnu.edu.cn shiziqi47@126.com.
  • Wu Q; Hunan Provincial Maternal and Child Health Care Hospital Changsha 410008 Hunan China.
  • Zhang S; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University Changsha 410013 Hunan China Xiaoping.Yang@hunnu.edu.cn shiziqi47@126.com.
  • Deng K; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University Changsha 410013 Hunan China Xiaoping.Yang@hunnu.edu.cn shiziqi47@126.com.
  • Zhang S; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University Changsha 410013 Hunan China Xiaoping.Yang@hunnu.edu.cn shiziqi47@126.com.
  • Shi ZQ; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University Changsha 410013 Hunan China Xiaoping.Yang@hunnu.edu.cn shiziqi47@126.com.
  • Yang X; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028 Jiangsu China.
RSC Adv ; 12(5): 3157-3164, 2022 Jan 18.
Article em En | MEDLINE | ID: mdl-35425325
Ru(bpy)3Cl2/TPrA is a prominent and widely used ECL system in analytical science. However, the co-reactant TPrA restricts the variety of applications because of its toxicity, volatility, and high cost. Here, we use arginine (Arg) as an alternative co-reactant for Ru(bpy)3 2+ by taking advantage of its low cost, non-toxicity, and biocompatibility. The mechanism of the Ru(bpy)3 2+/Arg system is that the deprotonated Arg can react with Ru(bpy)3 2+ to release emission. The similarity between the Ru(bpy)3 2+/Arg, Ru(bpy)3 2+/TPrA, and Ru(bpy)3 2+/DBAE systems demonstrates that Arg can be used as an alternative co-reactant for Ru(bpy)3 2+ ECL. As a proof of concept, we achieve an excellent performance for acetaminophen (Ace) detection based on the specificity of Arg and Ace, with excellent linearity, low detection limits, and good recoveries. This work is promising to expand the scope of the Ru(bpy)3 2+/Arg system and move forward their applications in bioassays.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: RSC Adv Ano de publicação: 2022 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: RSC Adv Ano de publicação: 2022 Tipo de documento: Article País de publicação: Reino Unido