Impacts of Cetylpyridinium Chloride on the Survival, Development, Behavior, and Oxidative Stress of Early-Life-Stage Zebrafish (Danio rerio).
Antioxidants (Basel)
; 11(4)2022 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-35453362
ABSTRACT
Cetylpyridinium chloride (CPC) is a widely used surfactant that has been detected in various water ecosystems. However, knowledge on the toxicity of CPC to fish remains scarce. Here, we examined the survival, development, behavior, and oxidative stress in the early life stages of zebrafish exposed to CPC (0, 4, 40, 400, and 1200 µg/L) until 120 h post-fertilization (hpf). Results showed that CPC induced significant mortality at 400 and 1200 µg/L, with a 120 h-EC50 value of 175.9 µg/L. CPC significantly decreased the heart rate of embryos (48 hpf; 4-400 µg/L) and larvae (72 hpf; 40 and 400 µg/L). At 120 hpf, CPC exhibited a dual effect on the locomotion activity (decreased at 400 µg/L and increased at 4 and 40 µg/L) and elevated the reactive oxygen species, superoxide dismutase, and glutathione levels in zebrafish larvae at 400 µg/L. In addition, a correlation analysis revealed that CPC-induced oxidative stress might play a critical role in mediating the cardiac and behavioral toxicity of CPC to zebrafish larvae. Our findings suggest that CPC may disturb the fish's development, behavior, and oxidative status at environmentally relevant concentrations, which should not be ignored when assessing its potential risks to aquatic ecosystems.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Antioxidants (Basel)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China