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AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.
Sheng, Nan; Wang, Yun-Qiu; Wang, Cun-Fu; Jia, Meng-Qi; Niu, Huan-Min; Lu, Qi-Qi; Wang, Ya-Nan; Feng, Dan; Zheng, Xiao-Xue; Yuan, Hui-Qing.
Afiliação
  • Sheng N; Key Laboratory of Experimental Teratology of Ministry of Education, Institute of Medical Sciences/Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, 250021, China.
  • Wang YQ; Key Laboratory of Experimental Teratology of Ministry of Education, Institute of Medical Sciences/Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, 250021, China.
  • Wang CF; Key Laboratory of Experimental Teratology of Ministry of Education, Institute of Medical Sciences/Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, 250021, China.
  • Jia MQ; Key Laboratory of Experimental Teratology of Ministry of Education, Institute of Medical Sciences/Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, 250021, China.
  • Niu HM; Key Laboratory of Experimental Teratology of Ministry of Education, Institute of Medical Sciences/Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, 250021, China.
  • Lu QQ; Key Laboratory of Experimental Teratology of Ministry of Education, Institute of Medical Sciences/Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, 250021, China.
  • Wang YN; Key Laboratory of Experimental Teratology of Ministry of Education, Institute of Medical Sciences/Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, 250021, China.
  • Feng D; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, 266021, China.
  • Zheng XX; Key Laboratory of Experimental Teratology of Ministry of Education, Institute of Medical Sciences/Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, 250021, China.
  • Yuan HQ; Key Laboratory of Experimental Teratology of Ministry of Education, Institute of Medical Sciences/Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, 250021, China. lyuanhq@sdu.edu.cn.
Acta Pharmacol Sin ; 43(11): 2905-2916, 2022 Nov.
Article em En | MEDLINE | ID: mdl-35459869
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Hidroximetilglutaril-CoA Redutases / Doença Hepática Crônica Induzida por Substâncias e Drogas / Hipercolesterolemia Limite: Animals Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Hidroximetilglutaril-CoA Redutases / Doença Hepática Crônica Induzida por Substâncias e Drogas / Hipercolesterolemia Limite: Animals Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos