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Lanolin Allergic Reactions: North American Contact Dermatitis Group Experience, 2001 to 2018.
Silverberg, Jonathan I; Patel, Nisha; Warshaw, Erin M; DeKoven, Joel G; Atwater, Amber R; Belsito, Donald V; Dunnick, Cory A; Houle, Marie-Claude; Reeder, Margo J; Maibach, Howard I; Zug, Kathryn A; Taylor, James S; Sasseville, Denis; Fransway, Anthony F; DeLeo, Vincent A; Pratt, Melanie D; Fowler, Joseph F; Zirwas, Matthew J.
Afiliação
  • Silverberg JI; From the Department of Dermatology, George Washington University School of Medicine, Washington, DC.
  • Patel N; From the Department of Dermatology, George Washington University School of Medicine, Washington, DC.
  • DeKoven JG; Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
  • Atwater AR; Department of Dermatology, Duke University Medical Center, Durham, NC.
  • Belsito DV; Department of Dermatology, Columbia University, New York, NY.
  • Dunnick CA; Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora.
  • Houle MC; Division of Dermatology, CHU de Québec, Laval University, Canada.
  • Reeder MJ; Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison.
  • Maibach HI; Department of Dermatology, University of California San Francisco.
  • Zug KA; Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
  • Taylor JS; Department of Dermatology, Cleveland Clinic, OH.
  • Sasseville D; Division of Dermatology, Montreal General Hospital, McGill University, Quebec, Canada.
  • Fransway AF; Associates in Dermatology, Fort Myers, FL.
  • DeLeo VA; Division of Dermatology, University of Ottawa, Ontario, Canada.
  • Pratt MD; Division of Dermatology, University of Louisville, KY.
  • Fowler JF; Department of Dermatology, Ohio State University, Columbus.
Dermatitis ; 33(3): 193-199, 2022.
Article em En | MEDLINE | ID: mdl-35481824
ABSTRACT

BACKGROUND:

Lanolin is an important cause of allergic contact dermatitis.

OBJECTIVES:

The aims of this study were to describe the epidemiology of lanolin allergy and to assess trends in patch test reactions to lanolin over time.

METHODS:

This study used a retrospective analysis of patients patch tested with lanolin alcohol 30% or Amerchol L-101 50% in petrolatum by the North American Contact Dermatitis Group between 2001 and 2018 (n = 43,691).

RESULTS:

Overall, 1431 (3.3%) had a positive reaction, and 1238 (2.8%) were currently relevant. Prevalence of lanolin allergy was 4.63% between 2011 and 2018 (P < 0.0001). Most lanolin-allergic patients had + (52%) reactions; 18%, and 6% had ++ and +++ reactions, respectively. Common primary anatomic sites of dermatitis were the hands (20.7%), scattered/generalized distribution (19.6%), and face (17.0%). Allergic reactions to lanolin were more common in children (4.5%) than in adults (3.2%, P = 0.0018). Compared with nonallergic patients, lanolin-allergic patients were more likely to have history of eczema or hay fever, male sex, older than 40 years, or Black race (P < 0.05). Common lanolin sources were personal care products and drugs/medications. Only 2.24% of the positive reactions were linked to occupation.

CONCLUSIONS:

Lanolin sensitivity was common. Reactions were often clinically relevant and linked to personal care products and medications.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dermatite Alérgica de Contato / Cosméticos Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Child / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Dermatitis Assunto da revista: DERMATOLOGIA Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dermatite Alérgica de Contato / Cosméticos Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Child / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Dermatitis Assunto da revista: DERMATOLOGIA Ano de publicação: 2022 Tipo de documento: Article