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Longitudinal Cognitive Changes in Genetic Frontotemporal Dementia Within the GENFI Cohort.
Poos, Jackie M; MacDougall, Amy; van den Berg, Esther; Jiskoot, Lize C; Papma, Janne M; van der Ende, Emma L; Seelaar, Harro; Russell, Lucy L; Peakman, Georgia; Convery, Rhian; Pijnenburg, Yolande A L; Moreno, Fermin; Sanchez-Valle, Raquel; Borroni, Barbara; Laforce, Robert; Doré, Marie-Claire; Masellis, Mario; Tartaglia, Maria Carmela; Graff, Caroline; Galimberti, Daniela; Rowe, James B; Finger, Elizabeth; Synofzik, Matthis; Vandenberghe, Rik; Mendonça, Alexandre; Tiraboschi, Pietro; Santana, Isabel; Ducharme, Simon; Butler, Christopher; Gerhard, Alexander; Levin, Johannes; Danek, Adrian; Otto, Markus; Le Ber, Isabelle; Pasquier, Florence; van Swieten, John; Rohrer, Jonathan D.
Afiliação
  • Poos JM; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • MacDougall A; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • van den Berg E; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Jiskoot LC; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Papma JM; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • van der Ende EL; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Seelaar H; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Russell LL; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Peakman G; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Convery R; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Pijnenburg YAL; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Moreno F; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Sanchez-Valle R; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Borroni B; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Laforce R; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Doré MC; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Masellis M; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Tartaglia MC; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Graff C; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Galimberti D; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Rowe JB; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Finger E; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Synofzik M; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Vandenberghe R; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Mendonça A; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Tiraboschi P; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Santana I; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Ducharme S; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Butler C; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Gerhard A; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Levin J; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Danek A; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Otto M; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Le Ber I; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Pasquier F; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • van Swieten J; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
  • Rohrer JD; From the Department of Neurology (J.M. Poos, E.v.d.B., L.C.J., J.M. Papma, E.L.v.d.E., H.S., J.v.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Dementia Research Centre (J.M. Poos, L.C.J., L.L.R., G.P., R.C., J.D.R.), Department of Neurodegenerative Disease, UCL Institute of
Neurology ; 99(3): e281-e295, 2022 07 19.
Article em En | MEDLINE | ID: mdl-35483895
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Disease-modifying therapeutic trials for genetic frontotemporal dementia (FTD) are underway, but sensitive cognitive outcome measures are lacking. The aim of this study was to identify such cognitive tests in early stage FTD by investigating cognitive decline in a large cohort of genetic FTD pathogenic variant carriers and by investigating whether gene-specific differences are moderated by disease stage (asymptomatic, prodromal, and symptomatic).

METHODS:

C9orf72, GRN, and MAPT pathogenic variant carriers as well as controls underwent a yearly neuropsychological assessment covering 8 cognitive domains as part of the Genetic FTD Initiative, a prospective multicenter cohort study. Pathogenic variant carriers were stratified according to disease stage using the global Clinical Dementia Rating (CDR) plus National Alzheimer's Coordinating Center (NACC) FTLD score (0, 0.5, or ≥1). Linear mixed-effects models were used to investigate differences between genetic groups and disease stages as well as the 3-way interaction between time, genetic group, and disease stage.

RESULTS:

A total of 207 C9orf72, 206 GRN, and 86 MAPT pathogenic variant carriers and 255 controls were included. C9orf72 pathogenic variant carriers performed lower on attention, executive function, and verbal fluency from CDR plus NACC FTLD 0 onwards, with relatively minimal decline over time regardless of the CDR plus NACC FTLD score (i.e., disease progression). The cognitive profile in MAPT pathogenic variant carriers was characterized by lower memory performance at CDR plus NACC FTLD 0.5, with decline over time in language from the CDR plus NACC FTLD 0.5 stage onwards, and executive dysfunction rapidly developing at CDR plus NACC FTLD ≥1. GRN pathogenic variant carriers declined on verbal fluency and visuoconstruction in the CDR plus NACC FTLD 0.5 stage, with progressive decline in other cognitive domains starting at CDR plus NACC FTLD ≥1.

DISCUSSION:

We confirmed cognitive decline in the asymptomatic and prodromal stage of genetic FTD. Specifically, tests for attention, executive function, language, and memory showed clear differences between genetic groups and controls at baseline, but the speed of change over time differed depending on genetic group and disease stage. This confirms the value of neuropsychological assessment in tracking clinical onset and progression and could inform clinical trials in selecting sensitive end points for measuring treatment effects as well as characterizing the best time window for starting treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Pick / Demência Frontotemporal Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Neurology Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Pick / Demência Frontotemporal Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Neurology Ano de publicação: 2022 Tipo de documento: Article