Dihydrosanguinarine based RNA-seq approach couple with network pharmacology attenuates LPS-induced inflammation through TNF/IL-17/PI3K/AKT pathways in mice liver.

Xiang, Yan; Zhang, Hao; Xu Zhang, Zheng; Yang Qu, Xiao; Xia Zhu, Fen

Xiang, Yan; Zhang, Hao; Xu Zhang, Zheng; Yang Qu, Xiao; Xia Zhu, Fen.

Afiliação

Xiang Y; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, PR China; Jiangsu Province Academy of Traditional Chinese Medicine, PR China.
Zhang H; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, PR China; Jiangsu Province Academy of Traditional Chinese Medicine, PR China.
Xu Zhang Z; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, PR China; Jiangsu Province Academy of Traditional Chinese Medicine, PR China.
Yang Qu X; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, PR China; Jiangsu Province Academy of Traditional Chinese Medicine, PR China.
Xia Zhu F; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, PR China; Jiangsu Province Academy of Traditional Chinese Medicine, PR China. Electronic address: zfxcjq@126.com.

Int Immunopharmacol ; 109: 108779, 2022 Aug.

Article em En | MEDLINE | ID: mdl-35490666

Assuntos

Anti-Inflamatórios; Benzofenantridinas; Inflamação; Isoquinolinas; Animais; Anti-Inflamatórios/farmacologia; Benzofenantridinas/farmacologia; Citocinas/metabolismo; Inflamação/induzido quimicamente; Inflamação/tratamento farmacológico; Interleucina-17/genética; Interleucina-6/genética; Isoquinolinas/farmacologia; Lipopolissacarídeos; Fígado/metabolismo; Camundongos; Farmacologia em Rede; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; RNA-Seq; Fator de Necrose Tumoral alfa/genética

Palavras-chave

Dihydrosanguinarine; LPS-induced liver inflammation; RNA-Seq; TNF/IL-17/PI3K-AKT signaling pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofenantridinas / Inflamação / Isoquinolinas / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda

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