A novel superfamily of bridge-like lipid transfer proteins.
Trends Cell Biol
; 32(11): 962-974, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-35491307
ABSTRACT
Lipid transfer proteins mediate nonvesicular transport of lipids at membrane contact sites to regulate the lipid composition of organelle membranes. Recently, a new type of bridge-like lipid transfer protein has emerged; these proteins contain a long hydrophobic groove and can mediate bulk transport of lipids between organelles. Here, we review recent insights into the structure of these proteins and identify a repeating modular unit that we propose to name the repeating ß-groove (RBG) domain. This new structural understanding conceptually unifies all the RBG domain-containing lipid transfer proteins as members of an RBG protein superfamily. We also examine the biological functions of these lipid transporters in normal physiology and disease and speculate on the evolutionary origins of RBG proteins in bacteria.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Membranas Mitocondriais
Limite:
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos