Hyperpolarized [5-13C,4,4-2H2,5-15N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine.

Eskandari, Roozbeh; Kim, Nathaniel; Mamakhanyan, Arsen; Saoi, Michelle; Zhang, Guannan; Berisaj, Marjan; Granlund, Kristin L; Poot, Alex J; Cross, Justin; Thompson, Craig B; Keshari, Kayvan R

Hyperpolarized [5-¹³C,4,4-²H₂,5-¹⁵N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine.

Eskandari, Roozbeh; Kim, Nathaniel; Mamakhanyan, Arsen; Saoi, Michelle; Zhang, Guannan; Berisaj, Marjan; Granlund, Kristin L; Poot, Alex J; Cross, Justin; Thompson, Craig B; Keshari, Kayvan R.

Afiliação

Eskandari R; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Kim N; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Mamakhanyan A; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Saoi M; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Zhang G; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Berisaj M; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Granlund KL; The Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Poot AJ; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Cross J; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Thompson CB; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Keshari KR; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.

Proc Natl Acad Sci U S A ; 119(19): e2120595119, 2022 05 10.

Article em En | MEDLINE | ID: mdl-35512101

Assuntos

Glutaminase; Glutamina; Biomarcadores/metabolismo; Ciclo do Ácido Cítrico; Glutaminase/metabolismo; Glutamina/metabolismo; Humanos; Metabolômica

Palavras-chave

cancer metabolism; magnetic resonance imaging; metabolic imaging; pancreatic cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glutaminase / Glutamina Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos

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