Synthesis and characterisation of &#945;-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology.

Zaitsev-Doyle, John J; Puchert, Anke; Pfeifer, Yannik; Yan, Hao; Yorke, Briony A; Müller-Werkmeister, Henrike M; Uetrecht, Charlotte; Rehbein, Julia; Huse, Nils; Pearson, Arwen R; Sans, Marta

Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology.

Zaitsev-Doyle, John J; Puchert, Anke; Pfeifer, Yannik; Yan, Hao; Yorke, Briony A; Müller-Werkmeister, Henrike M; Uetrecht, Charlotte; Rehbein, Julia; Huse, Nils; Pearson, Arwen R; Sans, Marta.

Afiliação

Zaitsev-Doyle JJ; The Hamburg Center for Ultrafast Imaging & Institute for Nanostructure and Solid State Physics Luruper Chaussee 149 22761 Hamburg Germany arwen.pearson@cfel.de marta.sans.valls@cfel.de.
Puchert A; Department of Physics and Centre for Hybrid Nanostructures, University of Hamburg Luruper Chaussee 149 22761 Hamburg Germany.
Pfeifer Y; University of Potsdam, Institute of Chemistry, Physical Chemistry Karl-Liebknecht-Str. 24-25, Golm 14476 Potsdam Germany.
Yan H; Heinrich Pette Institute, Leibniz Institute for Experimental Virology Martinistrasse 52 20251 Hamburg Germany.
Yorke BA; School of Chemistry, University of Leeds Leeds LS2 9JT UK.
Müller-Werkmeister HM; University of Potsdam, Institute of Chemistry, Physical Chemistry Karl-Liebknecht-Str. 24-25, Golm 14476 Potsdam Germany.
Uetrecht C; Heinrich Pette Institute, Leibniz Institute for Experimental Virology Martinistrasse 52 20251 Hamburg Germany.
Rehbein J; European XFEL GmbH Holzkoppel 4, 22869 Schenefeld Germany.
Huse N; Fachbereich für Chemie und Pharmazie, Universität Regensburg Universitätsstrasse 31 93053 Regensburg Germany.
Pearson AR; The Hamburg Center for Ultrafast Imaging & Institute for Nanostructure and Solid State Physics Luruper Chaussee 149 22761 Hamburg Germany arwen.pearson@cfel.de marta.sans.valls@cfel.de.
Sans M; Department of Physics and Centre for Hybrid Nanostructures, University of Hamburg Luruper Chaussee 149 22761 Hamburg Germany.

RSC Adv ; 9(15): 8695-8699, 2019 Mar 12.

Article em En | MEDLINE | ID: mdl-35518684

ABSTRACT

ABSTRACT

We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged l-aspartates for application in time-resolved structural biology. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates (τ = µs to ms) and quantum yields (φ = 0.05 to 0.14).

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: RSC Adv Ano de publicação: 2019 Tipo de documento: Article