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Identification and characterization of TYK2 pseudokinase domain stabilizers that allosterically inhibit TYK2 signaling.
Locke, Gregory A; Muckelbauer, Jodi; Tokarski, John S; Barbieri, Christopher M; Belic, Stefan; Falk, Bradley; Tredup, Jeffrey; Wang, Ying-Kai.
Afiliação
  • Locke GA; Leads Discovery and Optimization, Mechanistic Pharmacology, Bristol Myers Squib, Lawrenceville, NJ, United States. Electronic address: gregory.locke@bms.com.
  • Muckelbauer J; Leads Discovery and Optimization, Mechanistic Pharmacology, Bristol Myers Squib, Lawrenceville, NJ, United States.
  • Tokarski JS; Leads Discovery and Optimization, Mechanistic Pharmacology, Bristol Myers Squib, Lawrenceville, NJ, United States.
  • Barbieri CM; Leads Discovery and Optimization, Mechanistic Pharmacology, Bristol Myers Squib, Lawrenceville, NJ, United States.
  • Belic S; Leads Discovery and Optimization, Mechanistic Pharmacology, Bristol Myers Squib, Lawrenceville, NJ, United States.
  • Falk B; Leads Discovery and Optimization, Mechanistic Pharmacology, Bristol Myers Squib, Lawrenceville, NJ, United States.
  • Tredup J; Leads Discovery and Optimization, Mechanistic Pharmacology, Bristol Myers Squib, Lawrenceville, NJ, United States.
  • Wang YK; Leads Discovery and Optimization, Mechanistic Pharmacology, Bristol Myers Squib, Lawrenceville, NJ, United States.
Methods Enzymol ; 667: 685-727, 2022.
Article em En | MEDLINE | ID: mdl-35525559
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Janus Quinases / TYK2 Quinase Tipo de estudo: Diagnostic_studies Idioma: En Revista: Methods Enzymol Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Janus Quinases / TYK2 Quinase Tipo de estudo: Diagnostic_studies Idioma: En Revista: Methods Enzymol Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos