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Distinct infant feeding type-specific plasma metabolites at age 3 months associate with body composition at 2 years.
van Beijsterveldt, Inge A L P; Myers, Pernille Neve; Snowden, Stuart G; Ong, Ken K; Brix, Susanne; Hokken-Koelega, Anita C S; Koulman, Albert.
Afiliação
  • van Beijsterveldt IALP; Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Myers PN; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark; Clinical-Microbiomics A/S, CØpenhagen East, Denmark.
  • Snowden SG; Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; Department of Biological Sciences, Royal Holloway University of London, United Kingdom.
  • Ong KK; Medical Research Council Epidemiology Unit & Department of Paediatrics, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Brix S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.
  • Hokken-Koelega ACS; Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Koulman A; Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom. Electronic address: ak675@medschl.cam.ac.uk.
Clin Nutr ; 41(6): 1290-1296, 2022 06.
Article em En | MEDLINE | ID: mdl-35537379
BACKGROUND & OBJECTIVES: Early life is a critical window for adiposity programming and metabolic profile may affect this programming. We investigated if plasma metabolites at age 3 months were associated with fat mass, fat free mass and abdominal subcutaneous and visceral fat outcomes at age 2 years in a cohort of healthy infants and if these associations were different between infants receiving exclusive breastfeeding (EBF) and those with exclusive formula feeding (EFF). METHODS: In 318 healthy term-born infants, we determined body composition by Dual Energy X-ray absorptiometry (DXA) and visceral fat by abdominal ultrasound at 2 age years. High-throughput metabolic profiling was performed on blood samples collected at age 3 months. Tertiles were generated for each body composition outcome and differences in plasma metabolite levels at age 3 months between infants with high and low body composition outcomes at age 2 years were evaluated in general, as well as separately in EBF- and EFF-infants. RESULTS: Distinct plasma metabolite variables identified at age 3 months were associated with body composition at 2 years. These metabolites included several classes of lyso-phospholipids. Associations between the metabolites at age 3 months and fat mass index, fat mass percentage, fat free mass index and visceral fat at 2 years were predominantly found in EBF-infants. CONCLUSION: Associations between plasma metabolite levels at age 3 months and high body fat mass at 2 years depend on infant feeding type. These findings contribute to our insight into the importance of infant feeding on adiposity programming in early life.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Composição Corporal / Adiposidade Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Infant Idioma: En Revista: Clin Nutr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Composição Corporal / Adiposidade Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Infant Idioma: En Revista: Clin Nutr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido