Targeting HMGA protein inhibits retinoblastoma cell proliferation.

Balachandran, Akilandeswari; Zambre, Ajit; Kainth, Jagjot Singh; Nagarajha Selvan, Lakshmi Dhevi; Parameswaran, Sowmya; Afrasiabi, Zahra; Krishnakumar, Subramanian; Kannan, Raghuraman; Upendran, Anandhi

Balachandran, Akilandeswari; Zambre, Ajit; Kainth, Jagjot Singh; Nagarajha Selvan, Lakshmi Dhevi; Parameswaran, Sowmya; Afrasiabi, Zahra; Krishnakumar, Subramanian; Kannan, Raghuraman; Upendran, Anandhi.

Afiliação

Balachandran A; Department of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India drkk@snmail.org drkrishnakumar_2000@yahoo.com.
Zambre A; Department of Radiology, University of Missouri Columbia MO USA kannanr@health.missouri.edu.
Kainth JS; Department of Radiology, University of Missouri Columbia MO USA kannanr@health.missouri.edu.
Nagarajha Selvan LD; Department of Life Sciences, Lincoln University Jefferson City MO USA.
Parameswaran S; L&T Ocular Pathology Department, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India.
Afrasiabi Z; Radheshyam Kanoi Stem Cell Laboratory, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India.
Krishnakumar S; Department of Life Sciences, Lincoln University Jefferson City MO USA.
Kannan R; Department of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India drkk@snmail.org drkrishnakumar_2000@yahoo.com.
Upendran A; L&T Ocular Pathology Department, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India.

RSC Adv ; 8(55): 31510-31514, 2018 Sep 05.

Article em En | MEDLINE | ID: mdl-35548247

ABSTRACT

ABSTRACT

We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: RSC Adv Ano de publicação: 2018 Tipo de documento: Article