ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-&#954;B Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation.

Zhang, Shan-Shan; Liu, Man; Liu, Dong-Ni; Shang, Yu-Fu; Wang, Yue-Hua; Du, Guan-Hua

ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-κB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation.

Zhang, Shan-Shan; Liu, Man; Liu, Dong-Ni; Shang, Yu-Fu; Wang, Yue-Hua; Du, Guan-Hua.

Afiliação

Zhang SS; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Liu M; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Liu DN; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Shang YF; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Wang YH; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Du GH; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Molecules ; 27(9)2022 May 06.

Article em En | MEDLINE | ID: mdl-35566338

Assuntos

Lipopolissacarídeos; NF-kappa B; Animais; Caspase 1/metabolismo; Compostos Heterocíclicos com 2 Anéis; Interleucina-6/metabolismo; Lipopolissacarídeos/farmacologia; Masculino; Camundongos; Microglia; Fator 88 de Diferenciação Mieloide/metabolismo; NF-kappa B/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Doenças Neuroinflamatórias; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais; Compostos de Espiro; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

BV2 microglia cells; ST2825; lipopolysaccharide (LPS); neuroinflammation

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / NF-kappa B Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Suíça

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google