The circadian clock has roles in mesenchymal stem cell fate decision.
Stem Cell Res Ther
; 13(1): 200, 2022 05 16.
Article
em En
| MEDLINE
| ID: mdl-35578353
ABSTRACT
The circadian clock refers to the intrinsic biological rhythms of physiological functions and behaviours. It synergises with the solar cycle and has profound effects on normal metabolism and organismal fitness. Recent studies have suggested that the circadian clock exerts great influence on the differentiation of stem cells. Here, we focus on the close relationship between the circadian clock and mesenchymal stem cell fate decisions in the skeletal system. The underlying mechanisms include hormone signals and the activation and repression of different transcription factors under circadian regulation. Additionally, the clock interacts with epigenetic modifiers and non-coding RNAs and is even involved in chromatin remodelling. Although the specificity and safety of circadian therapy need to be further studied, the circadian regulation of stem cells can be regarded as a promising candidate for health improvement and disease prevention.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Relógios Circadianos
/
Células-Tronco Mesenquimais
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Stem Cell Res Ther
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China