Factors associated with the intention to participate in COVID-19 vaccine clinical trials: A cross-sectional study in Peru.

ABSTRACT

OBJECTIVE: To evaluate the factors associated with the intention to participate in COVID-19 vaccine clinical trials in the Peruvian population. METHODS: Cross-sectional study and secondary analysis of a database that involved Peruvian population during September 2020. The Poisson regression model was used to estimate the associated factors. RESULTS: Data from 3231 individuals were analyzed, 44.1% of whom intended to participate in COVID-19 vaccine clinical trials. Factors associated with the outcome were being male (RPa 1.25; 95% CI 1.15-1.35), being from the highlands region (RPa 1.18; 95% CI 1.09-1.28) or jungle (RPa 1.30; 95% CI 1.15-1.47), having a relative that is a healthcare professional (PRa 1.16; 95% CI 1.06-1.28), using a medical source of information (PRa 1.28; 95% CI 1.17-1.41), and trusting in the possible effectiveness of vaccines (PRa 1.40; 95% CI 1.29-1.51). The main reason for not participating in the trial was the possibility of developing side effects (69.80%). CONCLUSION: There is an urgent need to generate a perception of safety in COVID-19 vaccine clinical trials, to increase the population's intention to participate in these studies, and to provide evidence-based information about the vaccine.