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Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5.
Fang, Zhen; Mu, Bo; Liu, Yang; Guo, Nihong; Xiong, Liang; Guo, Yinping; Xia, Anjie; Zhang, Rong; Zhang, Hailin; Yao, Rui; Fan, Yan; Li, Linli; Yang, Shengyong; Xiang, Rong.
Afiliação
  • Fang Z; Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, 300071, China; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China.
  • Mu B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China; School of Basic Medical Sciences and Forensic Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
  • Liu Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China.
  • Guo N; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Xiong L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China.
  • Guo Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China.
  • Xia A; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China.
  • Zhang R; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China.
  • Zhang H; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China.
  • Yao R; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China.
  • Fan Y; Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, 300071, China.
  • Li L; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Yang S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, China. Electronic address: yangsy@scu.edu.cn.
  • Xiang R; Department of Medicinal Chemistry, School of Medicine, Nankai University, Tianjin, 300071, China. Electronic address: rxiang@nankai.edu.cn.
Eur J Med Chem ; 238: 114446, 2022 Aug 05.
Article em En | MEDLINE | ID: mdl-35597008
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA / Homólogo AlkB 5 da RNA Desmetilase Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA / Homólogo AlkB 5 da RNA Desmetilase Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: França