Modulation of Host Cell Signaling Pathways by Varicella-Zoster Virus.
Curr Top Microbiol Immunol
; 438: 75-84, 2023.
Article
em En
| MEDLINE
| ID: mdl-35624345
ABSTRACT
Host-pathogen interactions involve complex inside-out and outside-in signal transmission through critical cellular networks that dictate disease outcomes. The phosphoinositide 3-kinase (PI3K)/Akt pathway is a pivotal junction that regulates several cell functions, and phospho-Akt (pAkt) is often found to be constitutively active in cancer cells, similar to phospho-STAT3. In this chapter, we discuss the regulation of PI3K/Akt pathway in VZV infected cells and of other pathways including p53 which, unlike pAkt and pSTAT3, directs cells towards apoptosis. The fine spatio-temporal balance of activation of pro- and anti-apoptotic factors during VZV infection likely provides an optimum environment for the virus to replicate and cause disease in the human host.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Herpesvirus Humano 3
/
Fosfatidilinositol 3-Quinases
Limite:
Humans
Idioma:
En
Revista:
Curr Top Microbiol Immunol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos