Your browser doesn't support javascript.
loading
Ioxynil and diethylstilbestrol increase the risks of cardiovascular and thyroid dysfunction in zebrafish.
Li, Yi-Feng; Rodrigues, Joana; Campinho, Marco A.
Afiliação
  • Li YF; International Research Centre for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China; Centre of Marine Sciences, University of Algarve, Faro, Portugal.
  • Rodrigues J; Faculty of Science and Technology, University of the Algarve, Faro, Portugal.
  • Campinho MA; Centre of Marine Sciences, University of Algarve, Faro, Portugal; Faculty of Medicine and Biomedical Sciences, University of the Algarve, Faro, Portugal; Algarve Biomedical Center-Research Institute (ABC-RI), University of Algarve, Faro, Portugal. Electronic address: macampinho@ualg.pt.
Sci Total Environ ; 838(Pt 3): 156386, 2022 Sep 10.
Article em En | MEDLINE | ID: mdl-35662599
ABSTRACT
Endocrine disruption results from exposure to chemicals that alter the function of the endocrine system in animals. Chronic 60 days of exposure to a low dose (0.1 µM) of ioxynil (IOX) or diethylstilbestrol (DES) via food was used to determine the effects of these chemicals on the physiology of the heart and thyroid follicles in juvenile zebrafish. Immunofluorescence analysis and subsequent 3D morphometric analysis of the zebrafish heart revealed that chronic exposure to IOX induced ventricle deformation and significant volume increase (p < 0.001). DES exposure caused a change in ventricle morphology, but volume was unaffected. Alongside, it was found that DES exposure upregulated endothelial related genes (angptl1b, mhc1lia, mybpc2a, ptgir, notch1b and vwf) involved in vascular homeostasis. Both IOX and DES exposure caused a change in thyroid follicle morphology. Notably, in IOX exposed juveniles, thyroid follicle hypertrophy was observed; and in DES-exposed fish, an enlarged thyroid field was present. In summary, chronic exposure of juvenile zebrafish to IOX and DES affected the heart and the thyroid. Given that both chemicals are able to change the morphology of the thyroid it indicates that they behave as endocrine disruptive chemicals (EDCs). Heart function dynamically changes thyroid morphology, and function and hence it is likely that the observed cardiac effects of IOX and DES are the source of altered thyroid status in these fish.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Disruptores Endócrinos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Sci Total Environ Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Portugal

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Disruptores Endócrinos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Sci Total Environ Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Portugal