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Red wine but not alcohol consumption improves cardiovascular function and oxidative stress of the hypertensive-SHR and diabetic-STZ rats.
Souza Bomfim, Guilherme Henrique; Musial, Diego Castro; Rocha, Katiucha; Jurkiewicz, Aron; Jurkiewicz, Neide Hyppolito.
Afiliação
  • Souza Bomfim GH; Department of Molecular Pathobiology, New York University (NYU) College of Dentistry, NY, NY, USA.
  • Musial DC; Departamento de Farmacologia, Escola Paulista de Medicina da Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
  • Rocha K; Department of Molecular Pathobiology, New York University (NYU) College of Dentistry, NY, NY, USA.
  • Jurkiewicz A; Department of Molecular Pathobiology, New York University (NYU) College of Dentistry, NY, NY, USA.
  • Jurkiewicz NH; Department of Molecular Pathobiology, New York University (NYU) College of Dentistry, NY, NY, USA.
Clin Exp Hypertens ; 44(6): 573-584, 2022 Aug 18.
Article em En | MEDLINE | ID: mdl-35699125
ABSTRACT

AIMS:

This raised the issue of whether in vivo long-term red wine treatment can act as a modulator of these targets. MAIN

METHODS:

We monitored SBP, glucose tolerance, oxidative stress, and cardiovascular function. Aortic and atrial tissues from normotensive-WKY, hypertensive-SHR, and diabetic-STZ animals, chronically exposed to red wine (3.715 ml/kg/v.o/day) or alcohol (12%) for 21-days, were used to measure contractile/relaxation responses by force transducers. Key

findings:

red wine, but not alcohol, prevented the increase of SBP and hyperglycemic peak. Additionally, was observed prevention of oxidative stress metabolites formation and an improvement in ROS scavenging antioxidant capacity of SHR. We also revealed that red wine intake enhances the endothelium-dependent relaxation, decreases the hypercontractile mediated by angiotensin-II in the aorta, and via ß1-adrenoceptors in the atrium.

SIGNIFICANCE:

The long-term consumption of red wine can improve oxidative stress and the functionality of angiotensin-II and ß1-adrenoceptors, inspiring new pharmacologic and dietetic therapeutic approaches for the treatment of hypertension and diabetes.Abbreviation Acronyms and/or abbreviations [Ca2+]cyt = Cytosolic Ca2+ Concentration; ACh = Acetylcholine; ANG II = Angiotensin II; AT1 = ANG II type 1 receptor; AUC = Area Under the Curve; Ca2+ = Calcium; Endo + = Endothelium Intact; Fen = Phenylephrine (1 µM); GTT = Glucose Tolerance Test; ISO = Isoprenaline (isoproterenol); KHN = Krebs-Henseleit Nutrient; LA = Left Atria; LH = Lipid Hydroperoxide; NO = Nitric Oxide; RA = Right Atria; RAS = Renin-Angiotensin System; ROS = Reactive Oxygen Species; SBP = Systolic Blood Pressure; SHR = Spontaneously Hypertensive Rats; STZ = Streptozotocin; WKY = Normotensive Wistar Kyoto Rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vinho / Diabetes Mellitus / Hipertensão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Clin Exp Hypertens Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vinho / Diabetes Mellitus / Hipertensão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Clin Exp Hypertens Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos